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α(1) Proline 277 Residues Regulate GABA(A)R Gating through M2-M3 Loop Interaction in the Interface Region
[Image: see text] Cys-loop receptors are a superfamily of transmembrane, pentameric receptors that play a crucial role in mammalian CNS signaling. Physiological activation of these receptors is typically initiated by neurotransmitter binding to the orthosteric binding site, located at the extracellu...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9634794/ https://www.ncbi.nlm.nih.gov/pubmed/36219829 http://dx.doi.org/10.1021/acschemneuro.2c00401 |