Mechanochemistry Facilitates a Single-Crystal X-ray Structure Determination of Free Base Naloxone Anhydrate

[Image: see text] A method to obtain single crystals of the opioid antagonist naloxone in the free base form is facilitated using mechanochemistry. The application of mechanochemistry reduces the number of steps and makes single crystals readily available from solution compared to using an approach...

Descripción completa

Detalles Bibliográficos
Autores principales: Ortiz-de León, Celymar, Hartwick, Christopher J., Stuedemann, Clara A., Brogden, Nicole K., MacGillivray, Leonard R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9634803/
https://www.ncbi.nlm.nih.gov/pubmed/36345388
http://dx.doi.org/10.1021/acs.cgd.2c00831
_version_ 1784824576995229696
author Ortiz-de León, Celymar
Hartwick, Christopher J.
Stuedemann, Clara A.
Brogden, Nicole K.
MacGillivray, Leonard R.
author_facet Ortiz-de León, Celymar
Hartwick, Christopher J.
Stuedemann, Clara A.
Brogden, Nicole K.
MacGillivray, Leonard R.
author_sort Ortiz-de León, Celymar
collection PubMed
description [Image: see text] A method to obtain single crystals of the opioid antagonist naloxone in the free base form is facilitated using mechanochemistry. The application of mechanochemistry reduces the number of steps and makes single crystals readily available from solution compared to using an approach based exclusively on solution or the reported method based on sublimation. The X-ray structure confirms the structure determined using powder diffraction and provides details of hydrogen bonding.
format Online
Article
Text
id pubmed-9634803
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher American Chemical Society
record_format MEDLINE/PubMed
spelling pubmed-96348032022-11-05 Mechanochemistry Facilitates a Single-Crystal X-ray Structure Determination of Free Base Naloxone Anhydrate Ortiz-de León, Celymar Hartwick, Christopher J. Stuedemann, Clara A. Brogden, Nicole K. MacGillivray, Leonard R. Cryst Growth Des [Image: see text] A method to obtain single crystals of the opioid antagonist naloxone in the free base form is facilitated using mechanochemistry. The application of mechanochemistry reduces the number of steps and makes single crystals readily available from solution compared to using an approach based exclusively on solution or the reported method based on sublimation. The X-ray structure confirms the structure determined using powder diffraction and provides details of hydrogen bonding. American Chemical Society 2022-10-17 2022-11-02 /pmc/articles/PMC9634803/ /pubmed/36345388 http://dx.doi.org/10.1021/acs.cgd.2c00831 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Ortiz-de León, Celymar
Hartwick, Christopher J.
Stuedemann, Clara A.
Brogden, Nicole K.
MacGillivray, Leonard R.
Mechanochemistry Facilitates a Single-Crystal X-ray Structure Determination of Free Base Naloxone Anhydrate
title Mechanochemistry Facilitates a Single-Crystal X-ray Structure Determination of Free Base Naloxone Anhydrate
title_full Mechanochemistry Facilitates a Single-Crystal X-ray Structure Determination of Free Base Naloxone Anhydrate
title_fullStr Mechanochemistry Facilitates a Single-Crystal X-ray Structure Determination of Free Base Naloxone Anhydrate
title_full_unstemmed Mechanochemistry Facilitates a Single-Crystal X-ray Structure Determination of Free Base Naloxone Anhydrate
title_short Mechanochemistry Facilitates a Single-Crystal X-ray Structure Determination of Free Base Naloxone Anhydrate
title_sort mechanochemistry facilitates a single-crystal x-ray structure determination of free base naloxone anhydrate
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9634803/
https://www.ncbi.nlm.nih.gov/pubmed/36345388
http://dx.doi.org/10.1021/acs.cgd.2c00831
work_keys_str_mv AT ortizdeleoncelymar mechanochemistryfacilitatesasinglecrystalxraystructuredeterminationoffreebasenaloxoneanhydrate
AT hartwickchristopherj mechanochemistryfacilitatesasinglecrystalxraystructuredeterminationoffreebasenaloxoneanhydrate
AT stuedemannclaraa mechanochemistryfacilitatesasinglecrystalxraystructuredeterminationoffreebasenaloxoneanhydrate
AT brogdennicolek mechanochemistryfacilitatesasinglecrystalxraystructuredeterminationoffreebasenaloxoneanhydrate
AT macgillivrayleonardr mechanochemistryfacilitatesasinglecrystalxraystructuredeterminationoffreebasenaloxoneanhydrate

Ejemplares similares