Regulation of Blos1 by IRE1 prevents the accumulation of Huntingtin protein aggregates

Huntington’s disease is characterized by accumulation of the aggregation-prone mutant Huntingtin (mHTT) protein. Here, we show that expression of exon 1 of mHTT in mouse cultured cells activates IRE1, the transmembrane sensor of stress in the endoplasmic reticulum, leading to degradation of the Blos...

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Detalles Bibliográficos
Autores principales: Bae, Donghwi, Jones, Rachel Elizabeth, Piscopo, Katherine M., Tyagi, Mitali, Shepherd, Jason D., Hollien, Julie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9634971/
https://www.ncbi.nlm.nih.gov/pubmed/36044348
http://dx.doi.org/10.1091/mbc.E22-07-0281

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9634971/
https://www.ncbi.nlm.nih.gov/pubmed/36044348
http://dx.doi.org/10.1091/mbc.E22-07-0281

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