Cargando…

Single cell profiling of CD45(+) spinal cord cells reveals microglial and B cell heterogeneity and crosstalk following spinal cord injury

BACKGROUND: Immune cells play crucial roles after spinal cord injury (SCI). However, incomplete knowledge of immune contributions to injury and repair hinders development of SCI therapies. We leveraged single-cell observations to describe key populations of immune cells present in the spinal cord an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fisher, Elizabeth S., Amarante, Matthew A., Lowry, Natasha, Lotz, Steven, Farjood, Farhad, Temple, Sally, Hill, Caitlin E., Kiehl, Thomas R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9635187/ https://www.ncbi.nlm.nih.gov/pubmed/36333772 http://dx.doi.org/10.1186/s12974-022-02627-3

Ejemplares similares

Making Human Neurons from Stem Cells after Spinal Cord Injury
por: Lowry, Natalia Abramova, et al.
Publicado: (2007)

The core of maintaining neuropathic pain: Crosstalk between glial cells and neurons (neural cell crosstalk at spinal cord)
por: Zhang, Tianrui, et al.
Publicado: (2023)

Crosstalk between stem cell and spinal cord injury: pathophysiology and treatment strategies
por: Shao, Anwen, et al.
Publicado: (2019)

In vivo characterization of microglial engulfment of dying neurons in the zebrafish spinal cord
por: Morsch, Marco, et al.
Publicado: (2015)

BAF45D Downregulation in Spinal Cord Ependymal Cells Following Spinal Cord Injury in Adult Rats and Its Potential Role in the Development of Neuronal Lesions
por: Wang, Zhenzhen, et al.
Publicado: (2019)

Stem cell therapy for the spinal cord
por: Donnelly, Eleanor M, et al.
Publicado: (2012)

Stem Cells in Spinal Cord Injury
por: Wrathall, Jean R., et al.
Publicado: (2008)

Spinal Cord-derived Neural Precursor Cells as a Preventive Therapy for Spinal Cord Injury
por: Hosseini, Seyed Mojtaba, et al.
Publicado: (2018)

Microvascular endothelial cells derived from spinal cord promote spinal cord injury repair
por: You, Zhifeng, et al.
Publicado: (2023)

Single-cell analysis of the cellular heterogeneity and interactions in the injured mouse spinal cord
por: Milich, Lindsay M., et al.
Publicado: (2021)

Characterization of Ex Vivo and In Vitro Wnt Transcriptome Induced by Spinal Cord Injury in Rat Microglial Cells
por: González-Fernández, Carlos, et al.
Publicado: (2022)

Sex-distinct microglial activation and myeloid cell infiltration in the spinal cord after painful peripheral injury
por: Huck, Nolan A., et al.
Publicado: (2022)

Adult Mouse Leptomeninges Exhibit Regional and Age-related Cellular Heterogeneity Implicating Mental Disorders
por: Allen, Christina A., et al.
Publicado: (2023)

The Spinal Cord
por: Mauro, A.
Publicado: (1954)

Microglial voltage-gated proton channel Hv1 in spinal cord injury
por: Zheng, Jiaying, et al.
Publicado: (2021)

Fibrotic Scar After Spinal Cord Injury: Crosstalk With Other Cells, Cellular Origin, Function, and Mechanism
por: Li, Ziyu, et al.
Publicado: (2021)

Therapeutic effect of umbilical cord blood cells on spinal cord injury
por: Zhang, Jun‐Yan, et al.
Publicado: (2023)

ADAM17 is a survival factor for microglial cells in vitro and in vivo after spinal cord injury in mice
por: Vidal, P M, et al.
Publicado: (2013)

Transplantation of rat-derived microglial cells promotes functional recovery in a rat model of spinal cord injury
por: Kou, Dewei, et al.
Publicado: (2018)

Relationship between Spinal Cord Volume and Spinal Cord Injury due to Spinal Shortening
por: Qiu, Feng, et al.
Publicado: (2015)

Effect of Spinal Shortening for Protection of Spinal Cord Function in Canines with Spinal Cord Angulation
por: Lu, Qiu-An, et al.
Publicado: (2019)

Enrichment of spinal cord cell cultures with motoneurons
Publicado: (1978)

CELL DEATH IN THE EMBRYONIC CHICK SPINAL CORD
por: O'Connor, Thomas M., et al.
Publicado: (1974)

Stem cells for treatment of spinal cord injury
Publicado: (2012)

Stem Cells and Labeling for Spinal Cord Injury
por: Gazdic, Marina, et al.
Publicado: (2016)

Globose basal cells for spinal cord regeneration
por: Muniswami, Durai Murugan, et al.
Publicado: (2017)

Stem Cells Therapy for Spinal Cord Injury
por: Gazdic, Marina, et al.
Publicado: (2018)

Stem Cell Therapy for Spinal Cord Injury
por: Huang, Liyi, et al.
Publicado: (2021)

Cell type and circuit modules in the spinal cord
por: Osseward, Peter J, et al.
Publicado: (2019)

The Glial Cells Respond to Spinal Cord Injury
por: Wang, Ruideng, et al.
Publicado: (2022)

Role of regulatory T cells in spinal cord injury
por: Chen, Hao, et al.
Publicado: (2023)

Development of Spinal Cord Neurons in Delicate Balance
por: Sedwick, Caitlin
Publicado: (2014)

Organotypic Spinal Cord Slice Culture to Study Neural Stem/Progenitor Cell Microenvironment in the Injured Spinal Cord
por: Kim, Hyuk Min, et al.
Publicado: (2010)

Complete rat spinal cord transection as a faithful model of spinal cord injury for translational cell transplantation
por: Lukovic, Dunja, et al.
Publicado: (2015)

Human immune cells infiltrate the spinal cord and impair recovery after spinal cord injury in humanized mice
por: Carpenter, Randall S., et al.
Publicado: (2019)

An emerging role of inflammasomes in spinal cord injury and spinal cord tumor
por: Chen, Jiansong, et al.
Publicado: (2023)

Purinergic junctional transmission and propagation of calcium waves in cultured spinal cord microglial networks
por: Bennett, Max R., et al.
Publicado: (2007)

The microglial activation profile and associated factors after experimental spinal cord injury in rats
por: Zhou, Yuan, et al.
Publicado: (2018)

FANCC deficiency mediates microglial pyroptosis and secondary neuronal apoptosis in spinal cord contusion
por: Xia, Mingjie, et al.
Publicado: (2022)

Atractylenolide III ameliorates spinal cord injury in rats by modulating microglial/macrophage polarization
por: Xue, Meng‐Tong, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_qe7sa2oico4m1kg2r4gprn6ac4