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Long-term mitochondrial stress induces early steps of Tau aggregation by increasing reactive oxygen species levels and affecting cellular proteostasis

Accumulating evidence indicates that mitochondrial dysfunction is involved in the pathogenesis of neurodegenerative diseases. Both of these conditions are often associated with an increase in protein aggregation. However, still unknown are the specific defects of mitochondrial biology that play a cr...

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Detalles Bibliográficos
Autores principales: Samluk, Lukasz, Ostapczuk, Piotr, Dziembowska, Magdalena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9635289/
https://www.ncbi.nlm.nih.gov/pubmed/35446108
http://dx.doi.org/10.1091/mbc.E21-11-0553