WEE1 Inhibition Augments CDC7 (DDK) Inhibitor–induced Cell Death in Ewing Sarcoma by Forcing Premature Mitotic Entry and Mitotic Catastrophe

Ewing sarcoma is an aggressive childhood cancer for which treatment options remain limited and toxic. There is an urgent need for the identification of novel therapeutic strategies. Our group has recently shown that Ewing cells rely on the S-phase kinase cell division cycle 7 (CDC7) DBF4-dependent k...

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Detalles Bibliográficos
Autores principales: Martin, Jeffrey C., Sims, Jennie R., Gupta, Ajay, Bakin, Andrei V., Ohm, Joyce Ellen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9635308/
https://www.ncbi.nlm.nih.gov/pubmed/36338546
http://dx.doi.org/10.1158/2767-9764.CRC-22-0130

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9635308/
https://www.ncbi.nlm.nih.gov/pubmed/36338546
http://dx.doi.org/10.1158/2767-9764.CRC-22-0130

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