Cargando…

PIN1 protects auditory hair cells from senescence via autophagy

BACKGROUND: Age-related hearing loss is an increasing sensorineural hearing loss. But the pathogenesis of ARHL has not been clarified. Herein, we studied the role and significance of PIN1 in regulating autophagy activity in senescence HEI-OC1cells and HCs. METHODS AND RESULTS: C57BL/6 mice and HEI-O...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lv, Zhe, Zhang, Yanzhuo, Cao, Huan, Liu, Qingjuan, Feng, Xiaojuan, Yin, Huan, Wang, BaoShan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	PeerJ Inc. 2022
Materias:	Biochemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9635358/ https://www.ncbi.nlm.nih.gov/pubmed/36340199 http://dx.doi.org/10.7717/peerj.14267

Ejemplares similares

PIN1 Protects Hair Cells and Auditory HEI-OC1 Cells against Senescence by Inhibiting the PI3K/Akt/mTOR Pathway
por: Zhang, Yanzhuo, et al.
Publicado: (2021)

Long non-coding RNA NMRAL2P promotes glycolysis and reduces ROS in head and neck tumors by interacting with the ENO1 protein and promoting GPX2 transcription
por: Nie, Qian, et al.
Publicado: (2023)

Protective effect of astaxanthin nanoemulsion on mammalian inner ear hair cells
por: Kobayashi, Yuki, et al.
Publicado: (2023)

From hair to liver: emerging application of hair follicle mesenchymal stem cell transplantation reverses liver cirrhosis by blocking the TGF-β/Smad signaling pathway to inhibit pathological HSC activation
por: Liu, Qi, et al.
Publicado: (2022)

Autophagy protects auditory hair cells against neomycin-induced damage
por: He, Zuhong, et al.
Publicado: (2017)

Sclerostin promotes human dental pulp cells senescence
por: Ou, Yanjing, et al.
Publicado: (2018)

Hepatic nuclear factor 4 alpha promotes the ferroptosis of lung adenocarcinoma via transcriptional activation of cytochrome P450 oxidoreductase
por: Besskaya, Valeria, et al.
Publicado: (2023)

Therapeutic role of human hepatocyte growth factor (HGF) in treating hair loss
por: Qi, Yonghao, et al.
Publicado: (2016)

Human hair shaft proteomic profiling: individual differences, site specificity and cuticle analysis
por: Laatsch, Chelsea N., et al.
Publicado: (2014)

New insights into human hair: SAXS, SEM, TEM and EDX for Alopecia Areata investigations
por: Coroaba, Adina, et al.
Publicado: (2020)

Potential use of human hair shaft keratin peptide signatures to distinguish gender and ethnicity
por: Mohamed Nasir, Nurdiena, et al.
Publicado: (2020)

Heat treatment-induced autophagy promotes breast cancer cell invasion and metastasis via TGF-β2-mediated epithelial-mesenchymal transitions
por: Li, Zhennan, et al.
Publicado: (2023)

Overexpression of LINC00551 promotes autophagy-dependent ferroptosis of lung adenocarcinoma via upregulating DDIT4 by sponging miR-4328
por: Peng, Xiong, et al.
Publicado: (2022)

HNF4G increases cisplatin resistance in lung adenocarcinoma via the MAPK6/Akt pathway
por: Liang, Jiaqi, et al.
Publicado: (2023)

Bibliometric analysis of research on the trends in autophagy
por: Hong, Ting, et al.
Publicado: (2019)

Microorganism-regulated autophagy in gastrointestinal cancer
por: Xu, Jun-Yu, et al.
Publicado: (2023)

Identification of AaAtg8 as a marker of autophagy and a functional autophagy-related protein in Aedes albopictus
por: Qiao, Jialu, et al.
Publicado: (2018)

Full length RTN3 regulates turnover of tubular endoplasmic reticulum via selective autophagy
por: Grumati, Paolo, et al.
Publicado: (2017)

CAV1 alleviated CaOx stones formation via suppressing autophagy-dependent ferroptosis
por: Yang, Yuanyuan, et al.
Publicado: (2022)

Fat depot-specific differences of macrophage infiltration and cellular senescence in obese bovine adipose tissues
por: YAMADA, Tomoya, et al.
Publicado: (2018)

Tissue-specific expression of senescence biomarkers in spontaneously hypertensive rats: evidence of premature aging in hypertension
por: Somsura, Ratthapon, et al.
Publicado: (2023)

The Surgical Uses of the Hair Pin
Publicado: (1902)

Cathepsin B plays a role in spermatogenesis and sperm maturation through regulating autophagy and apoptosis in mice
por: Wen, Zongzhuang, et al.
Publicado: (2022)

Low-dose lipopolysaccharide inhibits spinal cord injury-induced neuronal apoptosis by regulating autophagy through the lncRNA MALAT1/Nrf2 axis
por: Hu, Jianhua, et al.
Publicado: (2023)

Senescent epithelial cells remodel the microenvironment for the progression of oral submucous fibrosis through secreting TGF-β1
por: Wang, Zijia, et al.
Publicado: (2023)

Involvement of TOB1 on autophagy in gastric cancer AGS cells via decreasing the activation of AKT/mTOR signaling pathway
por: Wang, Dong, et al.
Publicado: (2022)

Mechanism of cargo-directed Atg8 conjugation during selective autophagy
por: Fracchiolla, Dorotea, et al.
Publicado: (2016)

Chronic unpredictable mild stress promotes atherosclerosis via adipose tissue dysfunction in ApoE(-/-) mice
por: Mao, Min, et al.
Publicado: (2023)

Effect of apatinib on the pharmacokinetics of tramadol and O-desmethyltramadol in rats
por: Bao, Su-su, et al.
Publicado: (2023)

Translocation of interleukin-1β into a vesicle intermediate in autophagy-mediated secretion
por: Zhang, Min, et al.
Publicado: (2015)

The coordinated action of the MVB pathway and autophagy ensures cell survival during starvation
por: Müller, Martin, et al.
Publicado: (2015)

To protect or reject
por: Munson, Mary
Publicado: (2014)

Polypyrimidine tract binding protein 1 protects mRNAs from recognition by the nonsense-mediated mRNA decay pathway
por: Ge, Zhiyun, et al.
Publicado: (2016)

The role of autophagy in high-fat diet-induced insulin resistance of adipose tissues in mice
por: Budi, Yovita Permata, et al.
Publicado: (2022)

Oligomerization of p62 allows for selection of ubiquitinated cargo and isolation membrane during selective autophagy
por: Wurzer, Bettina, et al.
Publicado: (2015)

FGF19 promotes cell autophagy and cisplatin chemoresistance by activating MAPK signaling in ovarian cancer
por: Zhu, Wei, et al.
Publicado: (2023)

Progress in the mechanism of autophagy and traditional Chinese medicine herb involved in alcohol-related liver disease
por: Han, Wenwen, et al.
Publicado: (2023)

Elucidation of the anti-autophagy mechanism of the Legionella effector RavZ using semisynthetic LC3 proteins
por: Yang, Aimin, et al.
Publicado: (2017)

Melatonin ameliorates myocardial injury by reducing apoptosis and autophagy of cardiomyocytes in a rat cardiopulmonary bypass model
por: Huang, Xiaolin, et al.
Publicado: (2021)

The β-carboline alkaloid harmine inhibits telomerase activity of MCF-7 cells by down-regulating hTERT mRNA expression accompanied by an accelerated senescent phenotype
por: Zhao, Lei, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_d48pq1lvgc7onkp8fu87huv19f