Biological evaluation, docking studies, and in silico ADME prediction of some pyrimidine and pyridine derivatives as potential EGFR(WT) and EGFR(T790M) inhibitors

Herein, a set of pyridine and pyrimidine derivatives were assessed for their impact on the cell cycle and apoptosis. Human breast cancer (MCF7), hepatocellular carcinoma (HEPG2), larynx cancer (HEP2), lung cancer (H460), colon cancers (HCT116 and Caco2), and hypopharyngeal cancer (FADU), and normal...

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Detalles Bibliográficos
Autores principales: Al-Warhi, Tarfah, Al-Karmalawy, Ahmed A., Elmaaty, Ayman Abo, Alshubramy, Maha A., Abdel-Motaal, Marwa, Majrashi, Taghreed A., Asem, Medhat, Nabil, Ahmed, Eldehna, Wagdy M., Sharaky, Marwa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9635468/
https://www.ncbi.nlm.nih.gov/pubmed/36317648
http://dx.doi.org/10.1080/14756366.2022.2135512

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9635468/
https://www.ncbi.nlm.nih.gov/pubmed/36317648
http://dx.doi.org/10.1080/14756366.2022.2135512

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