Designer Gelators for the Crystallization of a Salt Active Pharmaceutical Ingredient—Mexiletine Hydrochloride

[Image: see text] We report an approach to obtain drug-mimetic supramolecular gelators, which are capable of stabilizing metastable polymorphs of the pharmaceutical salt mexiletine hydrochloride, a highly polymorphic antiarrhythmic drug. Solution-phase screening led to the discovery of two new solva...

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Detalles Bibliográficos
Autores principales: Andrews, Jessica L., Kennedy, Stuart R., Yufit, Dmitry S., McCabe, James F., Steed, Jonathan W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9635620/
https://www.ncbi.nlm.nih.gov/pubmed/36345390
http://dx.doi.org/10.1021/acs.cgd.2c00925

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9635620/
https://www.ncbi.nlm.nih.gov/pubmed/36345390
http://dx.doi.org/10.1021/acs.cgd.2c00925

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