Cargando…

Designer Gelators for the Crystallization of a Salt Active Pharmaceutical Ingredient—Mexiletine Hydrochloride

[Image: see text] We report an approach to obtain drug-mimetic supramolecular gelators, which are capable of stabilizing metastable polymorphs of the pharmaceutical salt mexiletine hydrochloride, a highly polymorphic antiarrhythmic drug. Solution-phase screening led to the discovery of two new solva...

Descripción completa

Detalles Bibliográficos
Autores principales:	Andrews, Jessica L., Kennedy, Stuart R., Yufit, Dmitry S., McCabe, James F., Steed, Jonathan W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9635620/ https://www.ncbi.nlm.nih.gov/pubmed/36345390 http://dx.doi.org/10.1021/acs.cgd.2c00925

Ejemplares similares

Highly Thermally Resistant Bisamide Gelators as Pharmaceutical Crystallization Media
por: Torres-Moya, Iván, et al.
Publicado: (2022)

The “Magic Linker”: Highly Effective Gelation from Sterically Awkward Packing
por: Smith, James P., et al.
Publicado: (2022)

Vapor Sorption and Halogen-Bond-Induced Solid-Form Rearrangement of a Porous Pharmaceutical
por: Andrews, Jessica L., et al.
Publicado: (2023)

The crystal engineering of radiation-sensitive diacetylene cocrystals and salts
por: Hall, Amy V., et al.
Publicado: (2020)

Microbatch under-oil salt screening of organic cations: single-crystal growth of active pharmaceutical ingredients
por: Babor, Martin, et al.
Publicado: (2019)

A patient with mexiletine-related psychosis
por: Shailesh, Fnu, et al.
Publicado: (2011)

Computer Aided Design of Solvent Blends for Hybrid Cooling and Antisolvent Crystallization of Active Pharmaceutical Ingredients
por: Watson, Oliver L., et al.
Publicado: (2021)

Alkali Metal Salts of 10,12-Pentacosadiynoic Acid and Their Dosimetry Applications
por: Hall, Amy V., et al.
Publicado: (2021)

Experience with oral mexiletine in primary erythromelalgia in children
por: Iqbal, Javeed, et al.
Publicado: (2009)

Molecular Modeling of Cardiac Sodium Channel with Mexiletine
por: Zhorov, Boris S.
Publicado: (2022)

Curative Effect of Yangxin Dingji Capsule Combined With Mexiletine Hydrochloride on Postoperative Arrhythmia and Its Influences on the Vascular Endothelial Function in Coronary Bifurcation Lesions
por: Sun, Nasha, et al.
Publicado: (2022)

Non-gelated polymeric photonic crystal films
por: Chu, Zhaoran, et al.
Publicado: (2022)

Synergistic Effect of Dofetilide and Mexiletine on Prevention of Atrial Fibrillation
por: Liu, Guizhi, et al.
Publicado: (2017)

Comparative efficacy of bepotastine besilate 1.5% ophthalmic solution versus olopatadine hydrochloride 0.2% ophthalmic solution evaluated by patient preference
por: McCabe, Craig F, et al.
Publicado: (2012)

Chemical Engineering in the Pharmaceutical Industry, Active Pharmaceutical Ingredients
por: Ende, David
Publicado: (2019)

Co-Crystals: A Novel Approach to Modify Physicochemical Properties of Active Pharmaceutical Ingredients
por: Yadav, A. V., et al.
Publicado: (2009)

Sample Preparation of Posaconazole Oral Suspensions for Identification of the Crystal Form of the Active Pharmaceutical Ingredient
por: Lykouras, Michail, et al.
Publicado: (2020)

Controlling Pharmaceutical Crystallization with Designed Polymeric Heteronuclei
por: Pfund, Laura Y., et al.
Publicado: (2014)

Scalable synthesis of (1-cyclopropyl)cyclopropylamine hydrochloride
por: Kozhushkov, Sergei I, et al.
Publicado: (2011)

Gelation and Crystallization Phenomena in Polyethylene Plastomers Modified with Waxes
por: Gahleitner, Markus, et al.
Publicado: (2021)

Spherical crystallization: A technique use to reform solubility and flow property of active pharmaceutical ingredients
por: Chatterjee, Arindam, et al.
Publicado: (2017)

Gelation Behaviors and Mechanism of Silk Fibroin According to the Addition of Nitrate Salts
por: Im, Dong Su, et al.
Publicado: (2016)

Influence of Glycerophosphate Salt Solubility on the Gelation Mechanism of Colloidal Chitosan Systems
por: Owczarz, Piotr, et al.
Publicado: (2021)

Characterization of Hydrochloride and Tannate Salts of Diphenhydramine
por: Nandgude, T. D., et al.
Publicado: (2008)

Digital Design of Filtration and Washing of Active Pharmaceutical Ingredients via Mechanistic Modeling
por: Ottoboni, Sara, et al.
Publicado: (2022)

Management of ventricular tachycardia--role of mexiletine : proceedings of a symposium held in Copenhagen, Denmark, 25th-27th May, 1978 /
Publicado: (1978)

A Case of Mexiletine-induced Hypersensitivity Syndrome Presenting as Eosinophilic Pneumonia
por: Lee, Sang-Pyo, et al.
Publicado: (2010)

Therapeutic drug monitoring of mexiletine at a large academic medical center
por: Nei, Scott D, et al.
Publicado: (2016)

Case report: Mexiletine suppresses ventricular arrhythmias in Andersen-Tawil syndrome
por: Yang, Jing, et al.
Publicado: (2022)

Mexiletine in spinal and bulbar muscular atrophy: a randomized controlled trial
por: Yamada, Shinichiro, et al.
Publicado: (2022)

Chiral Discrimination of Mexiletine Enantiomers by Capillary Electrophoresis Using Cyclodextrins as Chiral Selectors and Experimental Design Method Optimization
por: Cârcu-Dobrin, Melania, et al.
Publicado: (2022)

Designing Supramolecular Gelators: Challenges, Frustrations, and Hopes
por: Dastidar, Parthasarathi
Publicado: (2019)

Understanding the Interaction of Gluconamides and Gluconates with Amino Acids in Hair Care
por: Chambers, Luke I., et al.
Publicado: (2022)

Integrated Purification and Formulation of an Active Pharmaceutical Ingredient via Agitated Bed Crystallization and Fluidized Bed Processing
por: Stocker, Michael W., et al.
Publicado: (2022)

Study protocol for the MEXiletine hydrochloride administration trial: a placebo-controlled, randomised, double-blind, multicentre, crossover study of its efficacy and safety in spinal and bulbar muscular atrophy (MEXPRESS)
por: Yamada, Shinichiro, et al.
Publicado: (2018)

Tregitope Peptides: The Active Pharmaceutical Ingredient of IVIG?
por: De Groot, Anne S., et al.
Publicado: (2013)

Structure of the active pharmaceutical ingredient bismuth subsalicylate
por: Svensson Grape, Erik, et al.
Publicado: (2022)

Multicomponent Reactions for the Synthesis of Active Pharmaceutical Ingredients
por: Cores, Ángel, et al.
Publicado: (2022)

Hydrochloride Salt of the GABAkine KRM-II-81
por: Mian, Md Yeunus, et al.
Publicado: (2022)

Dynamic Behavior Analysis of Wax Crystals during Crude Oil Gelation
por: Dong, Hang, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_t9gagl441ldpseq8tjokskg3r7