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Adaptation of the yeast gene knockout collection is near-perfectly predicted by fitness and diminishing return epistasis
Adaptive evolution of clonally dividing cells and microbes is the ultimate cause of cancer and infectious diseases. The possibility of constraining the adaptation of cell populations, by inhibiting proteins enhancing the evolvability, has therefore attracted interest. However, our current understand...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9635671/ https://www.ncbi.nlm.nih.gov/pubmed/36083011 http://dx.doi.org/10.1093/g3journal/jkac240 |