All-trans retinoic acid (ATRA) regulates key genes in the RARG-TOP2B pathway and reduces anthracycline-induced cardiotoxicity

The effectiveness of anthracycline chemotherapeutics (e.g., doxorubicin) is limited by anthracycline-induced cardiotoxicity (ACT). A nonsynonymous variant (S427L) in the retinoic acid receptor-γ (RARG) gene has been associated with ACT. This variant causes reduced RARG activity, which is hypothesize...

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Detalles Bibliográficos
Autores principales: Hasbullah, Jafar S., Scott, Erika N., Bhavsar, Amit P., Gunaretnam, Erandika P., Miao, Fudan, Soliman, Hesham, Carleton, Bruce C., Ross, Colin J. D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9635745/
https://www.ncbi.nlm.nih.gov/pubmed/36331922
http://dx.doi.org/10.1371/journal.pone.0276541

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9635745/
https://www.ncbi.nlm.nih.gov/pubmed/36331922
http://dx.doi.org/10.1371/journal.pone.0276541

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