Loss of GPR40 in LDL receptor-deficient mice exacerbates high-fat diet-induced hyperlipidemia and nonalcoholic steatohepatitis

GPR40, a G protein-coupled receptor for free fatty acids (FFAs), is considered as a therapeutic target for type 2 diabetes mellitus (T2DM) since GPR40 activation in pancreatic beta cells enhances glucose-stimulated insulin secretion. Nonalcoholic fatty liver disease (NAFLD) is a common complication...

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Detalles Bibliográficos
Autores principales: Lu, Zhongyang, Li, Yanchun, Li, Ai-Jun, Syn, Wing-Kin, Wank, Stephen A., Lopes-Virella, Maria F., Huang, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9635748/
https://www.ncbi.nlm.nih.gov/pubmed/36331958
http://dx.doi.org/10.1371/journal.pone.0277251

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9635748/
https://www.ncbi.nlm.nih.gov/pubmed/36331958
http://dx.doi.org/10.1371/journal.pone.0277251

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