USP7 regulates the ncPRC1 Polycomb axis to stimulate genomic H2AK119ub1 deposition uncoupled from H3K27me3

Ubiquitin-specific protease 7 (USP7) has been implicated in cancer progression and neurodevelopment. However, its molecular targets remain poorly characterized. We combined quantitative proteomics, transcriptomics, and epigenomics to define the core USP7 network. Our multi-omics analysis reveals USP...

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Detalles Bibliográficos
Autores principales: Sijm, Ayestha, Atlasi, Yaser, van der Knaap, Jan A., Wolf van der Meer, Joyce, Chalkley, Gillian E., Bezstarosti, Karel, Dekkers, Dick H. W., Doff, Wouter A. S., Ozgur, Zeliha, van IJcken, Wilfred F. J., Demmers, Jeroen A. A., Verrijzer, C. Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9635827/
https://www.ncbi.nlm.nih.gov/pubmed/36332031
http://dx.doi.org/10.1126/sciadv.abq7598

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9635827/
https://www.ncbi.nlm.nih.gov/pubmed/36332031
http://dx.doi.org/10.1126/sciadv.abq7598

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