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Stress-induced glucocorticoid desensitizes adrenoreceptors to gate the neuroendocrine response to somatic stress in male mice
Noradrenergic afferents to hypothalamic corticotropin releasing hormone (CRH) neurons provide a major excitatory drive to the hypothalamic-pituitary-adrenal (HPA) axis via α1 adrenoreceptor activation. Noradrenergic afferents are recruited preferentially by somatic, rather than psychological, stress...
Autores principales: | Jiang, Zhiying, Chen, Chun, Weiss, Grant L., Fu, Xin, Stelly, Claire E., Sweeten, Brook L.W., Tirrell, Parker S., Pursell, India, Stevens, Carly R., Fisher, Marc O., Begley, John C., Harrison, Laura M., Tasker, Jeffrey G. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9635929/ https://www.ncbi.nlm.nih.gov/pubmed/36261014 http://dx.doi.org/10.1016/j.celrep.2022.111509 |
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