GBM tumors are heterogeneous in their fatty acid metabolism and modulating fatty acid metabolism sensitizes cancer cells derived from recurring GBM tumors to temozolomide

Glioblastoma is a highly lethal grade of astrocytoma with very low median survival. Despite extensive efforts, there is still a lack of alternatives that might improve these prospects. We uncovered that the chemotherapeutic agent temozolomide impinges on fatty acid synthesis and desaturation in newl...

Descripción completa

Detalles Bibliográficos
Autores principales: Parik, Sweta, Fernández-García, Juan, Lodi, Francesca, De Vlaminck, Karen, Derweduwe, Marleen, De Vleeschouwer, Steven, Sciot, Raf, Geens, Wietse, Weng, Linqian, Bosisio, Francesca Maria, Bergers, Gabriele, Duerinck, Johnny, De Smet, Frederick, Lambrechts, Diether, Van Ginderachter, Jo A., Fendt, Sarah-Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9635944/
https://www.ncbi.nlm.nih.gov/pubmed/36338708
http://dx.doi.org/10.3389/fonc.2022.988872

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9635944/
https://www.ncbi.nlm.nih.gov/pubmed/36338708
http://dx.doi.org/10.3389/fonc.2022.988872

Ejemplares similares