Glycerosomal thermosensitive in situ gel of duloxetine HCl as a novel nanoplatform for rectal delivery: in vitro optimization and in vivo appraisal

Duloxetine HCl (DXH) is a reuptake inhibitor of serotonin and norepinephrine used to treat the major depressive disorder. Following its extensive hepatic metabolism, acid-labile nature, and limited aqueous solubility, DXH has poor oral bioavailability (40%). The rectal route has been suggested as an...

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Detalles Bibliográficos
Autores principales: Salem, Heba F., Ali, Adel A., Rabea, Yasmine K., El-Ela, Fatma I. Abo, Khallaf, Rasha A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636110/
https://www.ncbi.nlm.nih.gov/pubmed/35622235
http://dx.doi.org/10.1007/s13346-022-01172-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636110/
https://www.ncbi.nlm.nih.gov/pubmed/35622235
http://dx.doi.org/10.1007/s13346-022-01172-z

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