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Glycerosomal thermosensitive in situ gel of duloxetine HCl as a novel nanoplatform for rectal delivery: in vitro optimization and in vivo appraisal

Duloxetine HCl (DXH) is a reuptake inhibitor of serotonin and norepinephrine used to treat the major depressive disorder. Following its extensive hepatic metabolism, acid-labile nature, and limited aqueous solubility, DXH has poor oral bioavailability (40%). The rectal route has been suggested as an...

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Detalles Bibliográficos
Autores principales:	Salem, Heba F., Ali, Adel A., Rabea, Yasmine K., El-Ela, Fatma I. Abo, Khallaf, Rasha A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636110/ https://www.ncbi.nlm.nih.gov/pubmed/35622235 http://dx.doi.org/10.1007/s13346-022-01172-z

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