Derepression of the USP22-FASN axis by p53 loss under oxidative stress drives lipogenesis and tumorigenesis

Overproduction of reactive oxygen species (ROS) and aberrant lipid metabolism are established hallmarks of cancer; however, the role of ROS in lipid synthesis during tumorigenesis is almost unknown. Herein, we show that ROS regulates lipid synthesis and thus controls colorectal tumorigenesis through...

Descripción completa

Detalles Bibliográficos
Autores principales: Han, Zelong, Liu, Ming, Xie, Yuxin, Zeng, Kunlin, Zhan, Ziling, Chen, Yanwen, Wang, Li, Chen, Xiaoxia, Luo, Yaxin, Zeng, Yu, Zhan, Hongchao, Lin, Yingzhuo, Zhang, Keqin, Zhu, Xiaoxia, Liu, Side, Luo, Xiaobei, Zhou, Aidong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636132/
https://www.ncbi.nlm.nih.gov/pubmed/36333288
http://dx.doi.org/10.1038/s41420-022-01241-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636132/
https://www.ncbi.nlm.nih.gov/pubmed/36333288
http://dx.doi.org/10.1038/s41420-022-01241-9

Ejemplares similares