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Reward expectation extinction restructures and degrades CA1 spatial maps through loss of a dopaminergic reward proximity signal

Hippocampal place cells support reward-related spatial memories by forming a cognitive map that over-represents reward locations. The strength of these memories is modulated by the extent of reward expectation during encoding. However, the circuit mechanisms underlying this modulation are unclear. H...

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Detalles Bibliográficos
Autores principales: Krishnan, Seetha, Heer, Chad, Cherian, Chery, Sheffield, Mark E. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636178/
https://www.ncbi.nlm.nih.gov/pubmed/36333323
http://dx.doi.org/10.1038/s41467-022-34465-5