Tumor factors stimulate lysosomal degradation of tumor antigens and undermine their cross-presentation in lung cancer

Activities of dendritic cells (DCs) that present tumor antigens are often suppressed in tumors. Here we report that this suppression is induced by tumor microenvironment-derived factors, which activate the activating transcription factor-3 (ATF3) transcription factor and downregulate cholesterol 25-...

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Detalles Bibliográficos
Autores principales: Lu, Zhen, Chen, Jinyun, Yu, Pengfei, Atherton, Matthew J., Gui, Jun, Tomar, Vivek S., Middleton, Justin D., Sullivan, Neil T., Singhal, Sunil, George, Subin S., Woolfork, Ashley G., Weljie, Aalim M., Hai, Tsonwin, Eruslanov, Evgeniy B., Fuchs, Serge Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636202/
https://www.ncbi.nlm.nih.gov/pubmed/36333297
http://dx.doi.org/10.1038/s41467-022-34428-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636202/
https://www.ncbi.nlm.nih.gov/pubmed/36333297
http://dx.doi.org/10.1038/s41467-022-34428-w

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