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Tumor factors stimulate lysosomal degradation of tumor antigens and undermine their cross-presentation in lung cancer
Activities of dendritic cells (DCs) that present tumor antigens are often suppressed in tumors. Here we report that this suppression is induced by tumor microenvironment-derived factors, which activate the activating transcription factor-3 (ATF3) transcription factor and downregulate cholesterol 25-...
| Autores principales: | , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636202/ https://www.ncbi.nlm.nih.gov/pubmed/36333297 http://dx.doi.org/10.1038/s41467-022-34428-w |