Parkin regulates adiposity by coordinating mitophagy with mitochondrial biogenesis in white adipocytes

Parkin, an E3 ubiquitin ligase, plays an essential role in mitochondrial quality control. However, the mechanisms by which Parkin connects mitochondrial homeostasis with cellular metabolism in adipose tissue remain unclear. Here, we demonstrate that Park2 gene (encodes Parkin) deletion specifically...

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Detalles Bibliográficos
Autores principales: Moore, Timothy M., Cheng, Lijing, Wolf, Dane M., Ngo, Jennifer, Segawa, Mayuko, Zhu, Xiaopeng, Strumwasser, Alexander R., Cao, Yang, Clifford, Bethan L., Ma, Alice, Scumpia, Philip, Shirihai, Orian S., Vallim, Thomas Q. de Aguiar, Laakso, Markku, Lusis, Aldons J., Hevener, Andrea L., Zhou, Zhenqi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636263/
https://www.ncbi.nlm.nih.gov/pubmed/36333379
http://dx.doi.org/10.1038/s41467-022-34468-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636263/
https://www.ncbi.nlm.nih.gov/pubmed/36333379
http://dx.doi.org/10.1038/s41467-022-34468-2

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