Anchoring IgG-degrading enzymes to the surface of platelets selectively neutralizes antiplatelet antibodies

Immune thrombocytopenia (ITP) is an acquired bleeding disorder characterized by immunoglobulin G (IgG)–mediated platelet destruction. Current therapies primarily focus on reducing antiplatelet antibodies using immunosuppression or increasing platelet production with thrombopoietin mimetics. However,...

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Detalles Bibliográficos
Autores principales: Lynch, Donald R., Stringham, Emily N., Zhang, Boya, Balbin-Cuesta, Ginette, Curtis, Brian R., Palumbo, Joseph S., Greineder, Colin F., Tourdot, Benjamin E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Hematology 2022
Materias:
Platelets and Thrombopoiesis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636316/
https://www.ncbi.nlm.nih.gov/pubmed/35737875
http://dx.doi.org/10.1182/bloodadvances.2022007195

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636316/
https://www.ncbi.nlm.nih.gov/pubmed/35737875
http://dx.doi.org/10.1182/bloodadvances.2022007195

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