In vivo HSC transduction in rhesus macaques with an HDAd5/3+ vector targeting desmoglein 2 and transiently overexpressing cxcr4

We developed a new in vivo hematopoietic stem cell (HSC) gene therapy approach that involves only IV injections and does not require myeloablation/conditioning and HSC transplantation. In this approach, HSCs are mobilized from the bone marrow into the peripheral bloodstream and transduced with IV in...

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Detalles Bibliográficos
Autores principales: Wang, Hongjie, Germond, Audrey, Li, Chang, Gil, Sucheol, Kim, Jiho, Kiem, Hans-Peter, Lieber, André
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Hematology 2022
Materias:
Gene Therapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636333/
https://www.ncbi.nlm.nih.gov/pubmed/35679480
http://dx.doi.org/10.1182/bloodadvances.2022007975

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636333/
https://www.ncbi.nlm.nih.gov/pubmed/35679480
http://dx.doi.org/10.1182/bloodadvances.2022007975

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