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Transplanting neurofibromatosis-1 gene knockout neural stem cells improve functional recovery in rats with spinal cord injury by enhancing the mTORC2 pathway

The poor survival and low efficiency of neuronal differentiation limits the therapeutic effects of transplanted neural stem cells in the treatment of spinal cord injury. Neurofibromatosis-1 (NF-1) is a tumor suppressor gene that restricts the rapid and abnormal growth and differentiation of neural c...

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Detalles Bibliográficos
Autores principales: Chen, Guoliang, Li, Xianlong, Zhu, Hongzhang, Wu, Huachuan, He, Dacheng, Shi, Liangyu, Wei, Fuxin, Liu, Xizhe, Chen, Ningning, Liu, Shaoyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636387/
https://www.ncbi.nlm.nih.gov/pubmed/36241865
http://dx.doi.org/10.1038/s12276-022-00850-9