EGFR-induced suppression of HPV E6/E7 is mediated by microRNA-9-5p silencing of BRD4 protein in HPV-positive head and neck squamous cell carcinoma

EGFR upregulation is an established biomarker of treatment resistance and aggressiveness in head and neck cancers (HNSCC). EGFR-targeted therapies have shown benefits for HPV-negative HNSCC; surprisingly, inhibiting EGFR in HPV-associated HNSCC led to inferior therapeutic outcomes suggesting opposin...

Descripción completa

Detalles Bibliográficos
Autores principales: Nantajit, Danupon, Presta, Luana, Sauter, Thomas, Tavassoli, Mahvash
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636399/
https://www.ncbi.nlm.nih.gov/pubmed/36333293
http://dx.doi.org/10.1038/s41419-022-05269-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636399/
https://www.ncbi.nlm.nih.gov/pubmed/36333293
http://dx.doi.org/10.1038/s41419-022-05269-8

Ejemplares similares