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Identification of a novel class of cyclic penta-peptides against hepatitis C virus as p7 channel blockers
The hepatitis C virus (HCV) p7 viroporin protein is essential for viral assembly and release, suggesting its unrealised potential as a target for HCV interventions. Several classes of small molecules that can inhibit p7 through allosteric mechanisms have shown low efficacy. Here, we used a high thro...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Research Network of Computational and Structural Biotechnology
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636413/ https://www.ncbi.nlm.nih.gov/pubmed/36382186 http://dx.doi.org/10.1016/j.csbj.2022.10.035 |