Identification of a novel class of cyclic penta-peptides against hepatitis C virus as p7 channel blockers

The hepatitis C virus (HCV) p7 viroporin protein is essential for viral assembly and release, suggesting its unrealised potential as a target for HCV interventions. Several classes of small molecules that can inhibit p7 through allosteric mechanisms have shown low efficacy. Here, we used a high thro...

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Detalles Bibliográficos
Autores principales: Wei, Shukun, Liu, Chaolun, Du, Lingyu, Wu, Bin, Zhong, Jin, Tong, Yimin, Wang, Shuqing, OuYang, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636413/
https://www.ncbi.nlm.nih.gov/pubmed/36382186
http://dx.doi.org/10.1016/j.csbj.2022.10.035

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