Creation and preclinical evaluation of genetically attenuated malaria parasites arresting growth late in the liver

Whole-sporozoite (WSp) malaria vaccines induce protective immune responses in animal malaria models and in humans. A recent clinical trial with a WSp vaccine comprising genetically attenuated parasites (GAP) which arrest growth early in the liver (PfSPZ-GA1), showed that GAPs can be safely administe...

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Detalles Bibliográficos
Autores principales: Franke-Fayard, Blandine, Marin-Mogollon, Catherin, Geurten, Fiona J. A., Chevalley-Maurel, Séverine, Ramesar, Jai, Kroeze, Hans, Baalbergen, Els, Wessels, Els, Baron, Ludivine, Soulard, Valérie, Martinson, Thomas, Aleshnick, Maya, Huijs, Antonius T. G., Subudhi, Amit K., Miyazaki, Yukiko, Othman, Ahmad Syibli, Kolli, Surendra Kumar, Lamers, Olivia A. C., Roques, Magali, Stanway, Rebecca R., Murphy, Sean C., Foquet, Lander, Moita, Diana, Mendes, António M., Prudêncio, Miguel, Dechering, Koen J., Heussler, Volker T., Pain, Arnab, Wilder, Brandon K., Roestenberg, Meta, Janse, Chris J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636417/
https://www.ncbi.nlm.nih.gov/pubmed/36333336
http://dx.doi.org/10.1038/s41541-022-00558-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636417/
https://www.ncbi.nlm.nih.gov/pubmed/36333336
http://dx.doi.org/10.1038/s41541-022-00558-x

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