AZIN1 RNA editing alters protein interactions, leading to nuclear translocation and worse outcomes in prostate cancer

The transcript encoding Antizyme Inhibitor 1 (AZIN1) is frequently edited in various cancers, and this editing is associated with enhanced tumor aggressiveness. After comparison of wild-type AZIN1 (wtAZIN1) and edited AZIN1 (edAZIN1, which contains a Ser367Gly substitution), we report differential b...

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Detalles Bibliográficos
Autores principales: Ghalali, Aram, Wang, Liangzhe, Stopsack, Konrad H., Rice, James M., Wu, Shulin, Wu, Chin-Lee, Zetter, Bruce R., Rogers, Michael S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636422/
https://www.ncbi.nlm.nih.gov/pubmed/36202978
http://dx.doi.org/10.1038/s12276-022-00845-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636422/
https://www.ncbi.nlm.nih.gov/pubmed/36202978
http://dx.doi.org/10.1038/s12276-022-00845-6

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