Downregulation of MACC1 facilitates the reversal effect of verapamil on the chemoresistance to active metabolite of irinotecan in human colon cancer cells

The aim of this study is to investigate the reversal effect of verapamil (VER) on chemoresistance to irinotecan (CPT-11) in human colon cancer cells and relevant mechanisms. Cell counting kit-8 (CCK-8) test and colony-forming unit (CFU) experiment results show that VER strengthens the sensitivity of...

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Detalles Bibliográficos
Autores principales: Qian, Xiaotao, Zhao, Yongxin, Zhang, Tengyue, Fan, Pingsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636468/
https://www.ncbi.nlm.nih.gov/pubmed/36345514
http://dx.doi.org/10.1016/j.heliyon.2022.e11294

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636468/
https://www.ncbi.nlm.nih.gov/pubmed/36345514
http://dx.doi.org/10.1016/j.heliyon.2022.e11294

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