BTK kinase activity is dispensable for the survival of diffuse large B-cell lymphoma

Inhibitors targeting Bruton's tyrosine kinase (BTK) have revolutionized the treatment for various B-cell malignancies but are limited by acquired resistance after prolonged treatment as a result of mutations in BTK. Here, by a combination of structural modeling, in vitro assays, and deep phosph...

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Detalles Bibliográficos
Autores principales: Yuan, Hongwei, Zhu, Yutong, Cheng, Yalong, Hou, Junjie, Jin, Fengjiao, Li, Menglin, Jia, Wei, Cheng, Zhenzhen, Xing, Haimei, Liu, Mike, Han, Ting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636578/
https://www.ncbi.nlm.nih.gov/pubmed/36183831
http://dx.doi.org/10.1016/j.jbc.2022.102555

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636578/
https://www.ncbi.nlm.nih.gov/pubmed/36183831
http://dx.doi.org/10.1016/j.jbc.2022.102555

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