Cargando…

Irradiation-induced exosomal HMGB1 to confer radioresistance via the PI3K/AKT/FOXO3A signaling pathway in ESCC

BACKGROUND: Radioresistance is a major cause of treatment failure in esophageal squamous cell carcinoma (ESCC) radiotherapy, and the underlying mechanisms of radioresistance are still unclear. Irradiation (IR) stimulates changes in tumor-derived exosome contents, which can be taken up by recipient c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Du, Xingyu, Zhang, Xueyuan, Dong, Jing, Zou, Naiyi, Guo, Dong, Yao, Weinan, Wang, Xiaobin, Li, Shuguang, Song, Chunyang, Yan, Ke, Shen, Wenbin, Zhu, Shuchai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636677/ https://www.ncbi.nlm.nih.gov/pubmed/36335371 http://dx.doi.org/10.1186/s12967-022-03720-0

Ejemplares similares

HMGB1 overexpression promotes a malignant phenotype and radioresistance in ESCC
por: Dong, Jing, et al.
Publicado: (2022)

HMGB1 induces radioresistance through PI3K/AKT/ATM pathway in esophageal squamous cell carcinoma
por: Zhang, Xueyuan, et al.
Publicado: (2022)

Elevated HNF1A expression promotes radiation-resistance via driving PI3K/AKT signaling pathway in esophageal squamous cell carcinoma cells
por: Zou, Naiyi, et al.
Publicado: (2021)

A novel DNA damage repair gene-related prognostic model for evaluating the prognosis and tumor microenvironment infiltration of esophageal squamous cell carcinoma
por: Guo, Dong, et al.
Publicado: (2023)

NEK2 promotes esophageal squamous cell carcinoma cell proliferation, migration and invasion through the Wnt/β-catenin signaling pathway
por: Guo, Dong, et al.
Publicado: (2023)

Association between RNF2+P-AKT expression in pretreatment biopsy specimens, and poor survival following radiotherapy in patients with esophageal squamous cell carcinoma
por: Li, Qiaofang, et al.
Publicado: (2019)

Targeting HMGB3/hTERT axis for radioresistance in cervical cancer
por: Li, Zongjuan, et al.
Publicado: (2020)

Patterns of failure and long-term outcome of postoperative radiotherapy on the survival of patients with pathological T3N0M0 esophageal cancer
por: Song, Chunyang, et al.
Publicado: (2022)

Exosomes in Cancer Radioresistance
por: Ni, Jie, et al.
Publicado: (2019)

Novel nomograms predicting the survival of patients with nonsurgical thoracic esophageal squamous cell carcinoma treated with IMRT: A retrospective analysis
por: Du, Xingyu, et al.
Publicado: (2022)

Gambogic acid affects ESCC progression through regulation of PI3K/AKT/mTOR signal pathway
por: Yu, Jiarui, et al.
Publicado: (2020)

mir-129-5p Attenuates Irradiation-Induced Autophagy and Decreases Radioresistance of Breast Cancer Cells by Targeting HMGB1
por: Luo, Jing, et al.
Publicado: (2015)

Promoter hypomethylation mediated upregulation of MicroRNA-10b-3p targets FOXO3 to promote the progression of esophageal squamous cell carcinoma (ESCC)
por: Lu, Yi-fang, et al.
Publicado: (2018)

Elective nodal irradiation provides a superior therapeutic modality for lymph node positivity esophageal squamous cell carcinoma patients receiving definitive radiotherapy versus involved-field irradiation
por: Li, Qiaofang, et al.
Publicado: (2019)

Effects of preoperative radiotherapy on survival of patients with stage II and III esophageal squamous cell carcinoma: A population-based study
por: Dong, Jing, et al.
Publicado: (2021)

Tumor-Secreted Exosomal lncRNA POU3F3 Promotes Cisplatin Resistance in ESCC by Inducing Fibroblast Differentiation into CAFs
por: Tong, Yusuo, et al.
Publicado: (2020)

Correction to: Promoter hypomethylation mediated upregulation of MicroRNA-10b-3p targets FOXO3 to promote the progression of esophageal squamous cell carcinoma (ESCC)
por: Lu, Yi-fang, et al.
Publicado: (2020)

ATF3 suppresses ESCC via downregulation of ID1
por: Li, Jian, et al.
Publicado: (2016)

MEX3A is upregulated in esophageal squamous cell carcinoma (ESCC) and promotes development and progression of ESCC through targeting CDK6
por: Wei, Lei, et al.
Publicado: (2020)

Nuclear exosome HMGB3 secreted by nasopharyngeal carcinoma cells promotes tumour metastasis by inducing angiogenesis
por: Zhang, Kaiwen, et al.
Publicado: (2021)

Wnt signaling induces radioresistance through upregulating HMGB1 in esophageal squamous cell carcinoma
por: Zhao, Yuanyuan, et al.
Publicado: (2018)

The immune mediated role of extracellular HMGB1 in a heterotopic model of bladder cancer radioresistance
por: Ayoub, Mina, et al.
Publicado: (2019)

Exosomal HMGB1 Promoted Cancer Malignancy
por: Wang, Jiaan-Der, et al.
Publicado: (2021)

UBE2C is overexpressed in ESCC tissues and its abrogation attenuates the malignant phenotype of ESCC cell lines
por: Palumbo, Antonio, et al.
Publicado: (2016)

Age plays an important role in the decision of definitive concurrent chemoradiotherapy (CCRT) for esophageal squamous cell carcinoma (ESCC): a propensity-score matched analysis of multicenter data (3JECROG R-02A)
por: Wang, Lan, et al.
Publicado: (2021)

Cancer-Secreted Exosomal MiR-620 Inhibits ESCC Aerobic Glycolysis via FOXM1/HER2 Pathway and Promotes Metastasis
por: Zhu, Yanbo, et al.
Publicado: (2022)

High TSTA3 Expression as a Candidate Biomarker for Poor Prognosis of Patients With ESCC
por: Yang, Jie, et al.
Publicado: (2018)

STAT3 Contributes to Radioresistance in Cancer
por: Wang, Xuehai, et al.
Publicado: (2020)

Prognosis and Progression of ESCC Patients with Perineural Invasion
por: Xu, Guanghui, et al.
Publicado: (2017)

Difference in Acquired Radioresistance Induction Between Repeated Photon and Particle Irradiation
por: Sato, Katsutoshi, et al.
Publicado: (2019)

The interaction of lncRNA EZR-AS1 with SMYD3 maintains overexpression of EZR in ESCC cells
por: Zhang, Xiao-Dan, et al.
Publicado: (2018)

Exosomal miR-590-3p derived from cancer-associated fibroblasts confers radioresistance in colorectal cancer
por: Chen, Xijuan, et al.
Publicado: (2020)

Overcoming radioresistance in WiDr cells with heavy ion irradiation and radiosensitization by 2-deoxyglucose with photon irradiation
por: Hasse, Felix Christian, et al.
Publicado: (2019)

Exosomes overexpressing miR-34c inhibit malignant behavior and reverse the radioresistance of nasopharyngeal carcinoma
por: Wan, Fang-Zhu, et al.
Publicado: (2020)

CircFOXO3 protects against osteoarthritis by targeting its parental gene FOXO3 and activating PI3K/AKT-mediated autophagy
por: Zhao, Chen, et al.
Publicado: (2022)

An emerging role of radiation-induced exosomes in hepatocellular carcinoma progression and radioresistance (Review)
por: Fan, Qing, et al.
Publicado: (2022)

Reply: Hookah, opium, and tobacco smoking in relation to ESCC
por: Malekzadeh, R, et al.
Publicado: (2009)

miR-378d suppresses malignant phenotype of ESCC cells through AKT signaling
por: Peng, Jie, et al.
Publicado: (2021)

Increased MCL-1 synthesis promotes irradiation-induced nasopharyngeal carcinoma radioresistance via regulation of the ROS/AKT loop
por: Liang, Ying-Ying, et al.
Publicado: (2022)

Polydatin inhibits hepatocellular carcinoma via the AKT/STAT3-FOXO1 signaling pathway
por: Jiang, Jian, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_oe6g7n2ienrf4qefjg117ovb02