Phosphorylation of RXRα mediates the effect of JNK to suppress hepatic FGF21 expression and promote metabolic syndrome

The cJun NH(2)-terminal kinase (JNK) signaling pathway in the liver promotes systemic changes in metabolism by regulating peroxisome proliferator-activated receptor α (PPARα)-dependent expression of the hepatokine fibroblast growth factor 21 (FGF21). Hepatocyte-specific gene ablation studies demonst...

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Detalles Bibliográficos
Autores principales: Vernia, Santiago, Lee, Alexandra, Kennedy, Norman J., Han, Myoung Sook, Isasa, Marta, Cavanagh-Kyros, Julie, Roy, Armanda, Syed, Aafreen, Chaudhry, Shanzah, Edwards, Yvonne J. K., Gygi, Steven P., Gao, Guangping, Davis, Roger J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636906/
https://www.ncbi.nlm.nih.gov/pubmed/36282921
http://dx.doi.org/10.1073/pnas.2210434119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636906/
https://www.ncbi.nlm.nih.gov/pubmed/36282921
http://dx.doi.org/10.1073/pnas.2210434119

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