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Phosphorylation of RXRα mediates the effect of JNK to suppress hepatic FGF21 expression and promote metabolic syndrome
The cJun NH(2)-terminal kinase (JNK) signaling pathway in the liver promotes systemic changes in metabolism by regulating peroxisome proliferator-activated receptor α (PPARα)-dependent expression of the hepatokine fibroblast growth factor 21 (FGF21). Hepatocyte-specific gene ablation studies demonst...
Autores principales: | Vernia, Santiago, Lee, Alexandra, Kennedy, Norman J., Han, Myoung Sook, Isasa, Marta, Cavanagh-Kyros, Julie, Roy, Armanda, Syed, Aafreen, Chaudhry, Shanzah, Edwards, Yvonne J. K., Gygi, Steven P., Gao, Guangping, Davis, Roger J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636906/ https://www.ncbi.nlm.nih.gov/pubmed/36282921 http://dx.doi.org/10.1073/pnas.2210434119 |
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