UM171 cooperates with PIM1 inhibitors to restrict HSC expansion markers and suppress leukemia progression

The pyrimido-indole derivative UM171 promotes human Hematopoietic Stem Cells Expansion (HSCE), but its impact on leukemia is not known. Herein, we show in a mouse model of erythroleukemia that UM171 strongly suppresses leukemia progression. UM171 inhibits cell cycle progression and apoptosis of leuk...

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Detalles Bibliográficos
Autores principales: Hu, Anling, Gao, Jian, Varier, Krishnapriya M., Gajendran, Babu, Jiang, Fei, Liu, Wuling, Wang, Chunlin, Xiao, Xiao, Li, Yanmei, Zacksenhaus, Eldad, Ali, Sajjad, Ben-David, Yaacov
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9637110/
https://www.ncbi.nlm.nih.gov/pubmed/36335089
http://dx.doi.org/10.1038/s41420-022-01244-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9637110/
https://www.ncbi.nlm.nih.gov/pubmed/36335089
http://dx.doi.org/10.1038/s41420-022-01244-6

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