Interaction of a viral insulin-like peptide with the IGF-1 receptor produces a natural antagonist

Lymphocystis disease virus-1 (LCDV-1) and several other Iridoviridae encode viral insulin/IGF-1 like peptides (VILPs) with high homology to human insulin and IGFs. Here we show that while single-chain (sc) and double-chain (dc) LCDV1-VILPs have very low affinity for the insulin receptor, scLCDV1-VIL...

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Detalles Bibliográficos
Autores principales: Moreau, Francois, Kirk, Nicholas S., Zhang, Fa, Gelfanov, Vasily, List, Edward O., Chrudinová, Martina, Venugopal, Hari, Lawrence, Michael C., Jimenez, Veronica, Bosch, Fatima, Kopchick, John J., DiMarchi, Richard D., Altindis, Emrah, Kahn, C. Ronald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9637144/
https://www.ncbi.nlm.nih.gov/pubmed/36335114
http://dx.doi.org/10.1038/s41467-022-34391-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9637144/
https://www.ncbi.nlm.nih.gov/pubmed/36335114
http://dx.doi.org/10.1038/s41467-022-34391-6

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