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Interaction of a viral insulin-like peptide with the IGF-1 receptor produces a natural antagonist
Lymphocystis disease virus-1 (LCDV-1) and several other Iridoviridae encode viral insulin/IGF-1 like peptides (VILPs) with high homology to human insulin and IGFs. Here we show that while single-chain (sc) and double-chain (dc) LCDV1-VILPs have very low affinity for the insulin receptor, scLCDV1-VIL...
Autores principales: | Moreau, Francois, Kirk, Nicholas S., Zhang, Fa, Gelfanov, Vasily, List, Edward O., Chrudinová, Martina, Venugopal, Hari, Lawrence, Michael C., Jimenez, Veronica, Bosch, Fatima, Kopchick, John J., DiMarchi, Richard D., Altindis, Emrah, Kahn, C. Ronald |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9637144/ https://www.ncbi.nlm.nih.gov/pubmed/36335114 http://dx.doi.org/10.1038/s41467-022-34391-6 |
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