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Acute severe hypoxia induces apoptosis of human pluripotent stem cells by a HIF-1α and P53 independent mechanism
Human embryonic and induced pluripotent stem cells are self-renewing pluripotent stem cells (hPSCs) that can differentiate into a wide range of specialized cells. Although moderate hypoxia (5% O(2)) improves hPSC self-renewal, pluripotency, and cell survival, the effect of acute severe hypoxia (1% O...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9637190/ https://www.ncbi.nlm.nih.gov/pubmed/36335243 http://dx.doi.org/10.1038/s41598-022-23650-7 |