Acute severe hypoxia induces apoptosis of human pluripotent stem cells by a HIF-1α and P53 independent mechanism

Human embryonic and induced pluripotent stem cells are self-renewing pluripotent stem cells (hPSCs) that can differentiate into a wide range of specialized cells. Although moderate hypoxia (5% O(2)) improves hPSC self-renewal, pluripotency, and cell survival, the effect of acute severe hypoxia (1% O...

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Detalles Bibliográficos
Autores principales: Mucci, Sofía, Isaja, Luciana, Rodríguez-Varela, María Soledad, Ferriol-Laffouillere, Sofía Luján, Marazita, Mariela, Videla-Richardson, Guillermo Agustín, Sevlever, Gustavo Emilio, Scassa, María Elida, Romorini, Leonardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9637190/
https://www.ncbi.nlm.nih.gov/pubmed/36335243
http://dx.doi.org/10.1038/s41598-022-23650-7

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