The Role of Single Nucleotide Polymorphisms in Transporter Proteins and the Folate Metabolism Pathway in Delayed Methotrexate Excretion: A Case Report and Literature Review

High-dose methotrexate (HDMTX) is a pivotal component of the chemotherapeutic regimens of osteosarcoma. However, the use of HDMTX is limited by an increased risk of dose-dependent toxicity. It is thought that the plasma levels and therapy-related toxicity of MTX could be associated with single nucle...

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Detalles Bibliográficos
Autores principales: Wang, Jun, Zhao, Yue-Tao, Sun, Meng-Jiao, Chen, Feng, Guo, Hong-Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9637359/
https://www.ncbi.nlm.nih.gov/pubmed/36349164
http://dx.doi.org/10.2147/PGPM.S376797

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9637359/
https://www.ncbi.nlm.nih.gov/pubmed/36349164
http://dx.doi.org/10.2147/PGPM.S376797

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