The Activity of Novel BCR-ABL Small-Molecule Degraders Containing Pyrimidine Rings and Their Role in Overcoming Drug Resistance

Inducing protein degradation by proteolysis-targeting chimeras (PROTACs) has gained tremendous momentum in the field for its promise in the discovery and development of new therapies. Based on our previously reported PROTAC BCR-ABL degraders, we designed and synthesized additional 4 PROTAC compounds...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Xu, Tu, Linglan, Chai, Haohuan, Li, Zilin, Fu, Yuhan, Zheng, Xiaoliang, Zeng, Shenxin, Cheng, Liyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9637472/
https://www.ncbi.nlm.nih.gov/pubmed/36349200
http://dx.doi.org/10.1155/2022/4056398

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9637472/
https://www.ncbi.nlm.nih.gov/pubmed/36349200
http://dx.doi.org/10.1155/2022/4056398

Ejemplares similares