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The Activity of Novel BCR-ABL Small-Molecule Degraders Containing Pyrimidine Rings and Their Role in Overcoming Drug Resistance

Inducing protein degradation by proteolysis-targeting chimeras (PROTACs) has gained tremendous momentum in the field for its promise in the discovery and development of new therapies. Based on our previously reported PROTAC BCR-ABL degraders, we designed and synthesized additional 4 PROTAC compounds...

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Detalles Bibliográficos
Autores principales:	Zhang, Xu, Tu, Linglan, Chai, Haohuan, Li, Zilin, Fu, Yuhan, Zheng, Xiaoliang, Zeng, Shenxin, Cheng, Liyan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9637472/ https://www.ncbi.nlm.nih.gov/pubmed/36349200 http://dx.doi.org/10.1155/2022/4056398

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