Rapid genomic changes by mineralotropic hormones and kinase SIK inhibition drive coordinated renal Cyp27b1 and Cyp24a1 expression via CREB modules

Vitamin D metabolism centers on kidney regulation of Cyp27b1 by mineralotropic hormones, including induction by parathyroid hormone (PTH), suppression by fibroblast growth factor 23 (FGF23) and 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)), and reciprocal regulations for Cyp24a1. This coordinated gen...

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Detalles Bibliográficos
Autores principales: Meyer, Mark B., Benkusky, Nancy A., Lee, Seong Min, Yoon, Sung-Hee, Mannstadt, Michael, Wein, Marc N., Pike, J. Wesley
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9637672/
https://www.ncbi.nlm.nih.gov/pubmed/36183832
http://dx.doi.org/10.1016/j.jbc.2022.102559

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9637672/
https://www.ncbi.nlm.nih.gov/pubmed/36183832
http://dx.doi.org/10.1016/j.jbc.2022.102559

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