Synthesis and Biological Evaluation of Cardiac Glycosides for Cancer Therapy by Targeting the DNA Damage Response

Cardiac glycosides (CGs) are bioactive compounds originally used to treat heart diseases, but recent studies have demonstrated their anticancer activity. We previously demonstrated that Antiaris toxicaria 2 (AT2) possesses anticancer activity in KRAS mutated lung cancers via impinging on the DNA dam...

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Detalles Bibliográficos
Autores principales: Ainembabazi, Diana, Geng, Xinran, Gavande, Navnath S., Turchi, John J., Zhang, Youwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9637767/
https://www.ncbi.nlm.nih.gov/pubmed/36054918
http://dx.doi.org/10.1002/cmdc.202200415

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9637767/
https://www.ncbi.nlm.nih.gov/pubmed/36054918
http://dx.doi.org/10.1002/cmdc.202200415

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