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Confirmation of high-throughput screening data and novel mechanistic insights into FXR-xenobiotic interactions by orthogonal assays

Toxicology in the 21st Century (Tox21) is a federal collaboration employing a high-throughput robotic screening system to test 10,000 environmental chemicals. One of the primary goals of the program is prioritizing toxicity evaluations through in vitro high-throughput screening (HTS) assays for larg...

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Detalles Bibliográficos
Autores principales: Hamm, Jon, Mahapatra, Debabrata, Knuth, Megan M., Abedini, Jaleh, Lingerfelt, Mary, Ekins, Sean, Kullman, Seth W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9637864/
https://www.ncbi.nlm.nih.gov/pubmed/36353521
http://dx.doi.org/10.1016/j.crtox.2022.100092