Multiple congenital malformations arise from somatic mosaicism for constitutively active Pik3ca signaling

Recurrent missense mutations of the PIK3CA oncogene are among the most frequent drivers of human cancers. These often lead to constitutive activation of its product p110α, a phosphatidylinositol 3-kinase (PI3K) catalytic subunit. In addition to causing a broad range of cancers, the H1047R mutation i...

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Detalles Bibliográficos
Autores principales: Marechal, Elise, Poliard, Anne, Henry, Kilian, Moreno, Mathias, Legrix, Mathilde, Macagno, Nicolas, Mondielli, Grégoire, Fauquier, Teddy, Barlier, Anne, Etchevers, Heather C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9637999/
https://www.ncbi.nlm.nih.gov/pubmed/36353506
http://dx.doi.org/10.3389/fcell.2022.1013001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9637999/
https://www.ncbi.nlm.nih.gov/pubmed/36353506
http://dx.doi.org/10.3389/fcell.2022.1013001

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