Human UFSP1 is an active protease that regulates UFM1 maturation and UFMylation

An essential first step in the post-translational modification of proteins with UFM1, UFMylation, is the proteolytic cleavage of pro-UFM1 to expose a C-terminal glycine. Of the two UFM1-specific proteases (UFSPs) identified in humans, only UFSP2 is reported to be active, since the annotated sequence...

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Detalles Bibliográficos
Autores principales: Millrine, David, Cummings, Thomas, Matthews, Stephen P., Peter, Joshua J., Magnussen, Helge M., Lange, Sven M., Macartney, Thomas, Lamoliatte, Frederic, Knebel, Axel, Kulathu, Yogesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9638016/
https://www.ncbi.nlm.nih.gov/pubmed/35926457
http://dx.doi.org/10.1016/j.celrep.2022.111168

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9638016/
https://www.ncbi.nlm.nih.gov/pubmed/35926457
http://dx.doi.org/10.1016/j.celrep.2022.111168

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