Succinate uptake by T cells suppresses their effector function via inhibition of mitochondrial glucose oxidation

Succinate dehydrogenase (SDH) loss-of-function mutations drive succinate accumulation in tumor microenvironments, for example in the neuroendocrine tumors pheochromocytoma (PC) and paraganglioma (PG). Control of innate immune cell activity by succinate is described, but effects on T cells have not b...

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Detalles Bibliográficos
Autores principales: Gudgeon, Nancy, Munford, Haydn, Bishop, Emma L., Hill, James, Fulton-Ward, Taylor, Bending, David, Roberts, Jennie, Tennant, Daniel A., Dimeloe, Sarah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9638018/
https://www.ncbi.nlm.nih.gov/pubmed/35977513
http://dx.doi.org/10.1016/j.celrep.2022.111193

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9638018/
https://www.ncbi.nlm.nih.gov/pubmed/35977513
http://dx.doi.org/10.1016/j.celrep.2022.111193

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